NMN vs NR: Viktiga skillnader
En helt ny auktoritativ studie är här! Ett experiment från 2025 av teamet vid Northwest A&F University, publicerat i Journal of Microbiology (Core Journal, DOI: 10.13343/j.cnki.wsxb.20250174), visade rigorös dat.a the true health effects of NMN and NR—two NAD+ precursors that both support gut health, fight inflammation and oxidation, yet each has its own distinct strengths. After reading this, you’ll never have to struggle over which to choose again!
DEL 01
The Common Power: NMN and NR Both Build the Body’s Foundation
The study divided 45 C57 mice into three groups: one control group drinking plain water, and two groups gavaged with NMN or NR (400 mg/(kg·d), 5 times per week). After 8 weeks, the results were astonishing: both compounds achieved consensus in regulating gut health and metabolism.
Ombalansering av tarmmikrobiotan: Fler nyttiga bakterier, mer stabilitet
The gut microbiota functions like a “miniature ecosystem”—the richer and more balanced it is, the healthier the host. The experiment found that after NMN or NR supplementation, the “richness” (Chao1 index) and “diversity” (Shannon index) of gut microbiota in mice increased significantly, meaning more beneficial bacteria and fewer harmful ones.
Figur 1: Effekter av NMN och NR som föda på intestinal mikrobiell mångfald hos möss.
A: Comparison of intestinal microbial α-diversity between the control and NMN groups;
B: Comparison of intestinal microbial α-diversity between the control and NR groups.
The dominant bacterial phyla also shifted: Bacteroidota (responsible for nutrient absorption and immune regulation) and Pseudomonadota increased, while Actinomycetota (associated with inflammation when imbalanced) decreased, without causing dysbiosis—essentially adding a “stabilizer” to the gut.
Figur 2: Effekter av NMN- och NR-födopåtaglighet på intestinal mikrobiell mångfald hos möss.
C: Stamförekomst på artnivå i den NMN-födda gruppen;
D: Stamnivåns artmängd i NR-födda gruppen
Antiinflammatorisk och antioxidant dubbel boost: Skydda hälsan från metabolism till gener
Inflammation och oxidativa skador är grundorsaker till många sjukdomar. NMN och NR bemöter dem från båda sidor:
Metabolically: both significantly upregulated anti-inflammatory fatty acid metabolites such as oleic acid and linoleic acid, as well as antioxidant metabolites like salicylic acid—adding a “natural defense shield” to the body.
Figur 3: Värmekarta över differentierade metaboliter i NMN-matade gruppen
Figur 4: Värmekarta över differentialmetaboliter i NR-fed-gruppen
Genetically: quantitative PCR testing confirmed that both compounds inhibited the expression of pro-inflammatory factors such as TNF-α and IL-6, effectively reducing inflammation at its source.
Figur 5: Effekter av att mata NMN och NR på tarminflammatoriska faktorer hos möss.
A: PCR expression of tumor necrosis factor-α (TNF-α);
B: PCR-uttryck av interleukin 6 (IL-6);
DEL 02
Viktiga skillnader: Att välja NMN eller NR för exakt hälsooptimering
While they share core benefits, the study clearly identified each compound’s area of expertise. Choose according to your needs for double the results.
NMN: The “Guardian” of Gut Barrier Health
If you often experience gut discomfort or worry about mucosal damage, NMN is the better choice. It significantly increases the number of goblet cells in the colon—these “mucus factories” secrete protective mucus that forms a physical barrier between harmful bacteria and intestinal epithelium, enhancing gut resistance. NMN also more strongly modulates gut microbiota diversity and strengthens local immunity through the “Bacteroidota–fatty acid” axis—essentially a personalized gut health solution.
Figur 6: Statistik över bägarceller i mustjocktarmen
Figure 7: Comparison of intestinal microbial α-diversity among mice in the control, NMN, and NR groups
NR: The “Booster” for Muscle Vitality
Want to improve muscle strength and reduce fatigue? NR shines here! Surprisingly, mice in the NR group showed significantly higher grip strength than those in the NMN and control groups. Mechanistically, NR upregulates metabolites like arachidic acid (for membrane repair) and L-asparagine (for energy optimization), activates core energy pathways such as the TCA cycle, and downregulates oxidative stress markers like hydroquinone—essentially “energizing and unburdening” muscles for peak performance.
Figure 8: Statistics of mice’s grasping ability
DEL 03
Choose According to Your Needs—Science Over Guesswork
Resultaten från 2025 gör det tydligt: NMN och NR är inte substitut utan kompletterande alternativ. Oavsett om ditt mål är att skydda tarmhälsan eller stärka fysisk vitalitet, ger valet av rätt NAD+-prekursor som stöds av auktoritativ litteratur din hälsa ett dubbelt lager av trygghet.
DEL 04
Bontac Bio’s NR Malate: Excellence in NR Technology and Quality
Sedan 2012 har Bontac Bio varit ett högteknologiskt företag specialiserat på biokatalysteknologi. Vid utvecklingen och produktionen av NR Malate (NRHM) integrerar företaget sin unika expertis och innovation, och visar upp enastående tekniska och produktmässiga fördelar.
Exclusive Technological Edge: Bontac Bio’s NR Malate holds the world’s first crystal form patent, achieving a molecular-level breakthrough that optimizes product performance. As a pioneer in the NMN industry, Bontac applies its globally original all-enzyme catalytic process—an innovation leading the industry. To date, the company has filed over 200 domestic and international invention patents and established China’s first provincial Coenzyme Engineering Technology Research Center, building strong competitive advantages through solid R&D strength.
Uncompromising Product Quality: Bontac enforces rigorous quality control standards. Third-party testing by CTI confirmed that NR Malate contains no detectable cadmium, mercury, lead, or arsenic—ensuring safety from the source. High-performance liquid chromatography revealed almost no impurity peaks, while moisture and microbial indicators far exceeded industry standards, reflecting exceptional purity. Critically, stability testing showed that under normal light-protected conditions, Bontac NR Malate degraded at only half the rate of regular NR (NRCL), ensuring reliable quality in both long-term storage and product applications.
Efterlevnad och certifiering: Bontac innehar FSSC 22000, Self-GRAS, FDA, Kosher och HALAL internationella certifieringar, vilket säkerställer full efterlevnad av globala standarder från forskning och utveckling till produktion. Ytterligare studier, inklusive tester mot fotoåldrande och zebrafisks NAD+-nivåer, bekräftade dess effektivitet och potential ytterligare.
Today, Bontac NR Malate is steadily advancing in compliant applications. For more insights into NR technology or premium product development, follow Bontac Bio—an industry leader in coenzyme biotechnology dedicated to sharing its R&D stories and quality standards.
DEL 01
The Common Power: NMN and NR Both Build the Body’s Foundation
The study divided 45 C57 mice into three groups: one control group drinking plain water, and two groups gavaged with NMN or NR (400 mg/(kg·d), 5 times per week). After 8 weeks, the results were astonishing: both compounds achieved consensus in regulating gut health and metabolism.
Ombalansering av tarmmikrobiotan: Fler nyttiga bakterier, mer stabilitet
The gut microbiota functions like a “miniature ecosystem”—the richer and more balanced it is, the healthier the host. The experiment found that after NMN or NR supplementation, the “richness” (Chao1 index) and “diversity” (Shannon index) of gut microbiota in mice increased significantly, meaning more beneficial bacteria and fewer harmful ones.
Figur 1: Effekter av NMN och NR som föda på intestinal mikrobiell mångfald hos möss.
A: Comparison of intestinal microbial α-diversity between the control and NMN groups;
B: Comparison of intestinal microbial α-diversity between the control and NR groups.
The dominant bacterial phyla also shifted: Bacteroidota (responsible for nutrient absorption and immune regulation) and Pseudomonadota increased, while Actinomycetota (associated with inflammation when imbalanced) decreased, without causing dysbiosis—essentially adding a “stabilizer” to the gut.
Figur 2: Effekter av NMN- och NR-födopåtaglighet på intestinal mikrobiell mångfald hos möss.
C: Stamförekomst på artnivå i den NMN-födda gruppen;
D: Stamnivåns artmängd i NR-födda gruppen
Antiinflammatorisk och antioxidant dubbel boost: Skydda hälsan från metabolism till gener
Inflammation och oxidativa skador är grundorsaker till många sjukdomar. NMN och NR bemöter dem från båda sidor:
Metabolically: both significantly upregulated anti-inflammatory fatty acid metabolites such as oleic acid and linoleic acid, as well as antioxidant metabolites like salicylic acid—adding a “natural defense shield” to the body.
Figur 3: Värmekarta över differentierade metaboliter i NMN-matade gruppen
Figur 4: Värmekarta över differentialmetaboliter i NR-fed-gruppen
Genetically: quantitative PCR testing confirmed that both compounds inhibited the expression of pro-inflammatory factors such as TNF-α and IL-6, effectively reducing inflammation at its source.
Figur 5: Effekter av att mata NMN och NR på tarminflammatoriska faktorer hos möss.
A: PCR expression of tumor necrosis factor-α (TNF-α);
B: PCR-uttryck av interleukin 6 (IL-6);
DEL 02
Viktiga skillnader: Att välja NMN eller NR för exakt hälsooptimering
While they share core benefits, the study clearly identified each compound’s area of expertise. Choose according to your needs for double the results.
NMN: The “Guardian” of Gut Barrier Health
If you often experience gut discomfort or worry about mucosal damage, NMN is the better choice. It significantly increases the number of goblet cells in the colon—these “mucus factories” secrete protective mucus that forms a physical barrier between harmful bacteria and intestinal epithelium, enhancing gut resistance. NMN also more strongly modulates gut microbiota diversity and strengthens local immunity through the “Bacteroidota–fatty acid” axis—essentially a personalized gut health solution.
Figur 6: Statistik över bägarceller i mustjocktarmen
Figure 7: Comparison of intestinal microbial α-diversity among mice in the control, NMN, and NR groups
NR: The “Booster” for Muscle Vitality
Want to improve muscle strength and reduce fatigue? NR shines here! Surprisingly, mice in the NR group showed significantly higher grip strength than those in the NMN and control groups. Mechanistically, NR upregulates metabolites like arachidic acid (for membrane repair) and L-asparagine (for energy optimization), activates core energy pathways such as the TCA cycle, and downregulates oxidative stress markers like hydroquinone—essentially “energizing and unburdening” muscles for peak performance.
Figure 8: Statistics of mice’s grasping ability
DEL 03
Choose According to Your Needs—Science Over Guesswork
Resultaten från 2025 gör det tydligt: NMN och NR är inte substitut utan kompletterande alternativ. Oavsett om ditt mål är att skydda tarmhälsan eller stärka fysisk vitalitet, ger valet av rätt NAD+-prekursor som stöds av auktoritativ litteratur din hälsa ett dubbelt lager av trygghet.
DEL 04
Bontac Bio’s NR Malate: Excellence in NR Technology and Quality
Sedan 2012 har Bontac Bio varit ett högteknologiskt företag specialiserat på biokatalysteknologi. Vid utvecklingen och produktionen av NR Malate (NRHM) integrerar företaget sin unika expertis och innovation, och visar upp enastående tekniska och produktmässiga fördelar.
Exclusive Technological Edge: Bontac Bio’s NR Malate holds the world’s first crystal form patent, achieving a molecular-level breakthrough that optimizes product performance. As a pioneer in the NMN industry, Bontac applies its globally original all-enzyme catalytic process—an innovation leading the industry. To date, the company has filed over 200 domestic and international invention patents and established China’s first provincial Coenzyme Engineering Technology Research Center, building strong competitive advantages through solid R&D strength.
Uncompromising Product Quality: Bontac enforces rigorous quality control standards. Third-party testing by CTI confirmed that NR Malate contains no detectable cadmium, mercury, lead, or arsenic—ensuring safety from the source. High-performance liquid chromatography revealed almost no impurity peaks, while moisture and microbial indicators far exceeded industry standards, reflecting exceptional purity. Critically, stability testing showed that under normal light-protected conditions, Bontac NR Malate degraded at only half the rate of regular NR (NRCL), ensuring reliable quality in both long-term storage and product applications.
Efterlevnad och certifiering: Bontac innehar FSSC 22000, Self-GRAS, FDA, Kosher och HALAL internationella certifieringar, vilket säkerställer full efterlevnad av globala standarder från forskning och utveckling till produktion. Ytterligare studier, inklusive tester mot fotoåldrande och zebrafisks NAD+-nivåer, bekräftade dess effektivitet och potential ytterligare.
Today, Bontac NR Malate is steadily advancing in compliant applications. For more insights into NR technology or premium product development, follow Bontac Bio—an industry leader in coenzyme biotechnology dedicated to sharing its R&D stories and quality standards.
